| Dartmouth at Penn | 6:00 pm | ESPNU / ESPN Video |
| Houston at Tulsa | 6:30 pm | ESPN / ESPN Video |
| Iowa at Maryland | 7:00 pm | FS1 / FOX Video |
| BYU at Utah State | 8:00 pm | CBSSN / CBS Video |
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College Football Open Thread | 2021.10.01
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